A New Approach to Complex Disease Care

Using precision medicine for the diagnosis, monitoring & tailored treatment of complex diseases

A New Approach to Complex Disease Care

At Ariel, we believe every patient is unique and their care should be too.

That’s why we launched ADVANCE®, a new precision medicine platform that is transforming genetic and clinical data into new insights for the diagnosis and management of complex health conditions.

Ariel Precision Medicine Unraveling the Complexity of Chronic Diseases Using Precision Medicine
Play Video

Advanced Intelligence for Complex Disease Care

Patients with a complex, chronic disorder don’t have a single cause for their disease. Each patient has a unique combination of genetic and environmental risk factors. Currently, many complex diseases are detected too late in their progression based on symptoms that can be misleading.

Ariel goes beyond genetics to provide valuable information to clarify risk and guide a personalized approach to the early detection of complex diseases such as pancreatitis and pancreatic cancer.

Our ADVANCE® analysis combines genetics, environmental and patient-specific data with clinical guidance supported by the most current scientific evidence to provide a comprehensive and actionable risk assessment to inform screening for early detection, risk-reducing strategies, and treatment.

Ariel analyzes a patient’s deep genetic sequencing and integrates the patient’s medical history and current symptoms to provide a comprehensive view of the factors that may be contributing to current conditions. Our genetic reporting provides genetic, biological markers along with evidence-based guidelines that are individualized to each patient.

Ariel Precision Medicine pancreatitis risk factors

Genetic Reports Integrate:


Medical and Family History

Genetic Information

Patient Health Profile

Lifestyle and Other Environmental Factors

ArielDx® Pancreatitis and Lipids

Comprehensive next-generation sequencing genetic risk assessment for pancreatitis and CFTR related disorders

ArielDx® Pancreatitis is a comprehensive next-generation sequencing panel of genes related to susceptibility to pancreatitis and related complications. ArielDx Pancreatitis tests for predisposition to both Mendelian (monogenic) and complex (multifactorial) forms of disease.

ArielDx® Lipids is a next-generation sequencing panel for genes associated with abnormal lipid metabolism. It is available as an add-on to ArielDx Pancreatitis during the ordering process.

genetics and pancreatitis

ArielDx® Pancreatic Cancer

Early risk assessment for pancreatic cancer

A 14-gene targeted sequencing panel for established moderate to high penetrance genes associated with risk of pancreatic ductal adenocarcinoma (PDAC). *Deletion/duplication studies only.

Genes targeted have the most clinical evidence for genetic risk for pancreatic cancer. These genes are associated with established risks for cancer and management guidelines.

ArielDx® Pharmacogenomics

Next-generation sequencing for pharmacogenomics

ArielDx® Pharmacogenomics is a clinical genetic test and interpretation service. We incorporate patient-specific clinical data along with information from FDA prescription drug labeling and evidence-based clinical practice guidelines from the Clinical Pharmacogenetics Implementation Consortium (CPIC). Our unique individualized approach provides informative and actionable PGx data in an easy-to-interpret report. ArielDx Pharmacogenomics can be added-on to any ArielDx Pancreatitis order and may be appropriate for anyone who is currently taking or will be taking a medication.

Pharmacogenomics Reports Include:

Data from 11 genes related to drug metabolism (pharmacokinetics) and action (pharmacodynamics)

Multi drug-gene pairs supported by FDA labeling and CPIC

Clinical Significance

Full List of Called Pharmacogenomics Haplotypes

References and Resources

Panel Description

ADVANCE® Precision Medicine Platform

ADVANCE® is a clinical decision support platform that simplifies diagnosis and helps guide a more personalized management strategy at the earliest signs of pancreatic diseases.

ADVANCE integrates an individual’s genetics, environment, and family and medical history to provide clinicians more actionable insights into complex diseases, including evidence-based knowledge for management and treatment options. Our AI powered technology combines deep genetic sequencing with advanced analytics and evidence-based knowledge to provide genetic testing and a report that is actionable and easy to use.

How Ariel Helps Providers


Unravel Complex Conditions

Integrates a patient’s symptoms and genetics with medical information and curated evidence-based clinical considerations.

Ariel expertise

Secure Online Test Management

Order and review test results, add medical team and request patient consent using our portal.


Comprehensive Genetic Testing

Analyzes multiple risk factors that are disease causing rather than just assessing single gene risk factors.

As an MD, I am frustrated with the lack of effective treatment for pancreatic diseases. As a PhD, I am excited about new breakthroughs in knowledge and possibilities for the future. As a member of the Ariel Team, I am thrilled to see science meet medicine to provide those future solutions – NOW!

David Whitcomb, MD, PhD

Co-Founder and Chairman, Ariel Precision Medicine
David C. Whitcomb, MD, PhD Co-Founder and Chief Scientific Officer, Ariel Precision Medicine

How Ariel Helps Patients


Understand Symptoms and Risk Factors

Gain a better understanding of unknown risk factors and whether you have a genetic cause for your condition, or an increased genetic susceptibility to it.


Help for Pancreatitis

Comprehensive genetic testing and pre- and/or post-test genetic counseling.

icon-early diagnosis

Timely Diagnosis

Timely diagnosis can prevent costly and invasive diagnostic procedures, and allow for intervention prior to reaching end-stage disease.

Convenient at Home Testing

Easy-to-use & non-invasive DNA collection using a saliva sample is done at home and then sent to our lab for analysis.

Research Services

Targeted Next-Generation DNA Sequencing

Targeted next-generation DNA sequencing (NGS) enabling high-throughput and rapid results for clinical and research applications.

SARS CoV-2 Array Genotyping


High-throughput, cost-effective genotyping and associated bioinformatics services for small to large-scale research-initiatives.

Bioinformatics Services


Multidisciplinary team of physicians, computer scientists, biologists, and bioinformaticians providing customized analysis of biological data from a wide variety of genotyping and sequencing platforms.

Recognition and Awards

Ariel has been recognized by several organizations for it’s outstanding work in healthcare and technology.

Ariel Precision Medicine awards

Let Ariel Be Your Expert

You don’t have to be an expert in genetics.

We help you translate complex genetic data into a more personalized care plan. So, you can focus on optimal care instead of sifting through complicated genetic information.

Ariel Insights and News