That’s why we launched ADVANCE®, a new advanced genetics platform designed specifically for providers to identify and diagnose the underlying biological causes of symptoms and move beyond treating general symptoms.
In addition to traditional Mendelian variants, Ariel reports disease modifying and complex genetic variants.
Our reports are tailored to each patient, integrating patient reported outcomes, environmental and medical history into the interpretation of the genetic data.
Our expert system provides you with clinical considerations according to guidelines and continuously updates you and your patients if variants are reclassified.
Our platform uses some of the highest quality next-generation sequencing on the market and our laboratory is CLIA-certified.
PancreasDx® is a comprehensive next-generation sequencing panel of genes related to susceptibility to pancreatitis and related complications. PancreasDx tests for predisposition to both Mendelian (monogenic) and complex (multifactorial) forms of disease. A minority of pancreatitis patients have a monogenic cause of disease. Therefore, testing for predisposing risk variants in addition to monogenic disease variants assures a complete picture of known genetic predisposition.
Genes Included in Panel
CASR, CEL, CFTR, CLDN2, CPA1, CTRC, GGT1, PRSS1-2, PRSS3, SBDS, SLC26A9, SPINK1 and UBR1.
ArielDx® Lipids analyzes genetic susceptibility to hypertriglyceridemia, the presence of elevated triglycerides, a type of fat (lipid), in the blood.
Hypertriglyceridemia increases an individual’s risk for developing cardiovascular disease, fatty liver disease, and pancreatitis. Severe hypertriglyceridemia is an established cause of pancreatitis, accounting for up to 10% of acute pancreatitis cases . Variants in several genes can cause hereditary disorders of lipid metabolism or increase an individual’s risk for hypertriglyceridemia. Genetic testing may be helpful in determining the underlying cause of a patient’s disease and provide clinical guidance for targeted treatment.
ArielDx Lipids may be appropriate for individuals with a personal or familial history of hypertriglyceridemia and pancreatitis. It is available as an add-on to PancreasDx during the ordering process.
Genes Included in Panel
APOA5, APOC2, FABP4, LPL, PPARG, GPIHBP1 and a region of interest in APOB exon 29.
Pancreatitis has several different causes that largely depend on the specific genetic and environmental risk factors involved and their interactions. The disease subtypes require markedly different approaches to management and involve different treatments and likely outcomes. PancreasDx incorporates genetic sequencing information, patient health records and environmental exposures to provide a personalized guide for patient management.
Our platform integrates a patient’s symptoms and genetics with complex medical information.
Pre- and/or post-test genetic counseling if you need extra help with genetic testing.
Analyzes multiple risk factors that are disease causing rather than just assessing single gene risk factors.
Order and review test results, add medical team and request patient consent using our portal.
There is growing evidence that suggests that most diseases of the pancreas have a genetic predisposition or basis. Genetic testing can help provide advanced insights to help you create a comprehensive and more personalized clinical management plan for your patient.
As an MD, I am frustrated with the lack of effective treatment for pancreatic diseases. As a PhD, I am excited about new breakthroughs in knowledge and possibilities for the future. As a member of the Ariel Team, I am thrilled to see science meet medicine to provide those future solutions – NOW!
Co-Founder and Chairman, Ariel Precision Medicine
Frequently asked questions about PancreasDx, ArielDx Lipids, Ariel Precision Medicine,
and how you can use genetic information to improve outcomes for your patients.
Genetic testing for pancreatitis is recommended for individuals with pancreatitis that meet one or more of the following criteria:
Additionally, individuals that meet any of the following criteria may also benefit from genetic testing:
Ariel’s test goes beyond genetics to incorporate genetic testing, patient medical and family history, patient biomarkers, and up-to-date management considerations to provide a comprehensive and actionable precision medicine report.
PancreasDx tests for predisposition to both Mendelian (monogenic) and complex (multifactorial) forms of disease. A minority of pancreatitis patients have a monogenic cause of disease. Therefore, testing for predisposing risk variants in addition to monogenic disease variants assures a complete picture of known genetic predisposition.
PancreasDx® is a comprehensive next-generation sequencing panel of genes related to susceptibility to pancreatitis and related complications.
ArielDx® Lipid is a next-generation sequencing panel of genes related to genetic susceptibility to hypertriglyceridemia, a predisposing factor to pancreatitis. ArielDx®Lipid is available as an add-on to PancreasDx® during the ordering process.
Ariel is committed to a streamlined and convenient ordering and results disclosure process:
Ariel accepts all insurance plans. As a new provider, we are not considered an in-network provider with all insurance plans. While the organization continues to grow, Ariel will work towards establishing in-network status.
The Ariel team follows the process below:
Ariel is required by law to bill patients for applicable co-pays, co-insurance, and deductibles, as directed by their individual insurance beneﬁt plan. Ariel will partner with the patient to implement the most appropriate payback plan based on the individual’s financial need.
Depending on the patient’s insurance plan, there may be situations where Ariel is considered an out-of-network provider and the payment for our test will be sent to the patient directly. The patient is legally responsible for re-issuing that payment, with a copy of the Explanation of Beneﬁts, to Ariel for processing.
To ensure that PancreasDx is accessible to medically necessary patients, several options are available to support any patient out-of-pocket costs remaining after all billing efforts are exhausted with the insurance plan. Available options include payment plans, prompt pay discounts, and ﬁnancial assistance, based on individual need.
Yes. Ariel offers genetic counseling services for patients through an independent third-party genetic counseling provider over video or phone. Pre-test genetic counseling through a third-party is complimentary with every test, which clinicians can request with every order. A request for post-test genetic counseling can be made through the Ariel provider portal. At that time, the patient’s contact information and PancreasDx® test results are provided to a third-party genetic counseling service. This third party service will contact the patient to discuss cost and scheduling.
Ariel offers educational materials on pancreatitis, genetic testing, complex disease and other pertinent topics for clinicians and patients inside the portal. Patient counseling materials for use during informed consent discussions and test ordering are available.
Ariel also offers genetic counseling services for patients through an independent third-party genetic counseling provider over video or phone. Pre-test genetic counseling through a third party is included as an option with every test, which clinicians can request with every order. A request for post-test genetic counseling can be made through the Ariel provider portal. At that time, the patient’s contact information and PancreasDx® test results are provided to a third-party genetic counseling service. This third-party service will contact the patient to discuss cost and scheduling.
Please tell your patient to expect an email from Ariel. Once you place an order in the secure portal, Ariel will send your patient a ‘Welcome’ email with a link to Ariel’s secure patient portal to register. The patient can then follow the instructions in their email to register in Ariel’s online portal, provide their insurance information and complete the informed consents and their patient profile. Once the requisite forms are compete, Ariel dispatches a DNA testing kit to the patient’s house. This kit also has all the necessary instructions for collecting the sample and shipping it back to Ariel.
If you still have questions, we would love to answer them. Request a quick call with our team and we’ll be in touch.